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Isolated somatotropin deficiency

MedGen UID:
811475
•Concept ID:
C3714796
•
Disease or Syndrome
Synonym: GH deficiency
SNOMED CT: Isolated somatotropin deficiency (2109003); Isolated growth hormone deficiency (2109003); Isolated growth hormone insufficiency (2109003); IGHD - Isolated growth hormone deficiency (2109003)

Definition

Insufficient production of growth hormone. [from NCI]

Professional guidelines

PubMed

Developments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan.
Miller BS, Blair J, Horikawa R, Linglart A, Yuen KCJ
Drug Des Devel Ther 2024;18:291-306. Epub 2024 Feb 3 doi: 10.2147/DDDT.S315172. PMID: 38333899Free PMC Article
Recommendations for Diagnosis and Treatment of Pseudohypoparathyroidism and Related Disorders: An Updated Practical Tool for Physicians and Patients.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Garcia Ramirez A, Germain-Lee EL, Groussin L, Hamdy NAT, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Horm Res Paediatr 2020;93(3):182-196. Epub 2020 Aug 5 doi: 10.1159/000508985. PMID: 32756064Free PMC Article
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.
Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR
Endocr Pract 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405. PMID: 31760824

Recent clinical studies

Etiology

Urinary cyclic adenosine 3',5'-monophosphate excretion in children in short stature: effect of somatotropin.
Raij K, Perheentupa J, Härkönen M
Scand J Clin Lab Invest 1977 Dec;37(8):713-6. doi: 10.3109/00365517709101854. PMID: 203022

Therapy

Hereditary isolated somatotropin deficiency: effects of human growth hormone administration.
Sheikholislam BM, Stempfel RS Jr
Pediatrics 1972 Mar;49(3):362-74. PMID: 5010465

Supplemental Content

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